rs2953145

A SNP in the RNPEPL1 gene on chromosome 2. Its most notable genotype is G;G: normal

Gene
RNPEPL1
Location
Chr 2240,576,179 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
14%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.03% of people
  2. C;GNot rated1.8x riskTypical · 0.026% of people
  3. C;CNot rated2.1x riskTypical · 0.071% of people

SNPedia records rs2953145 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 3% C;G 26% C;C 71%
  • European ancestry (Utah)G;G 4% C;G 33% C;C 64%
  • Han Chinese (Beijing)G;G 0% C;G 9% C;C 91%
  • Japanese (Tokyo)G;G 0% C;G 4% C;C 97%
  • Yoruba (Nigeria)G;G 3% C;G 35% C;C 61%
  • African ancestry (Southwest US)G;G 2% C;G 30% C;C 68%
  • Chinese (Denver)G;G 0% C;G 3% C;C 97%
  • Gujarati IndianG;G 3% C;G 41% C;C 56%
  • Luhya (Kenya)G;G 6% C;G 35% C;C 59%
  • Mexican ancestry (Los Angeles)G;G 0% C;G 17% C;C 83%
  • Maasai (Kenya)G;G 9% C;G 40% C;C 51%
  • TuscanG;G 9% C;G 38% C;C 53%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2953145 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.84 (CI 1.31-2.58), and for homozygotes, 2.14 (CI 1.53-2.98).

Source and license

Adapted from rs2953145 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.