rs2968863

A SNP on chromosome 7. Its most notable genotype is T;T: Possibly slightly higher (2.4x) risk for atrial fibrillation

Gene
None listed
Location
Chr 7150,926,049 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
13%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadPossibly slightly higher (2.4x) risk for atrial fibrillationWorth knowing · 2.01% of people
  2. C;CGoodcommon/normalTypical · 0.087% of people

SNPedia records rs2968863 on the minus strand: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 1% C;C 87%
  • European ancestry (Utah)T;T 5% C;C 58%
  • Han Chinese (Beijing)T;T 0% C;C 96%
  • Japanese (Tokyo)T;T 0% C;C 98%
  • Yoruba (Nigeria)T;T 0% C;C 95%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A 2013 study of 358 atrial fibrillation patients with early-onset (before the age of 50) reported that rs2968863(A;A) individuals had higher AF risk (OR 2.40, p = 0.001 and p= 0.016 after Bonferroni correction). Heterozygotes were not at increased risk. As that study stated, the rs2968863 variant had previously been shown in GWAS studies to decrease the QTc interval by 1.4ms.

T;T

see text and links via main rs-page

Source and license

Adapted from rs2968863 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.