rs3003609

A SNP in the DNM1 gene on chromosome 9. Its most notable genotype is C;C: normal

Gene
DNM1
Location
Chr 9128,222,476 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormalTypical · 0.040% of people
  2. C;TNot rated?Typical · 0.037% of people
  3. T;TNot ratedassociated with heavier smoking in CaucasiansTypical · 0.023% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 40% C;T 37% T;T 23%
  • European ancestry (Utah)C;C 18% C;T 49% T;T 34%
  • Han Chinese (Beijing)C;C 19% C;T 48% T;T 33%
  • Japanese (Tokyo)C;C 15% C;T 53% T;T 32%
  • Yoruba (Nigeria)C;C 99% C;T 1% T;T 0%
  • African ancestry (Southwest US)C;C 68% C;T 30% T;T 2%
  • Chinese (Denver)C;C 12% C;T 51% T;T 37%
  • Gujarati IndianC;C 19% C;T 42% T;T 40%
  • Luhya (Kenya)C;C 86% C;T 15% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 12% C;T 52% T;T 36%
  • Maasai (Kenya)C;C 68% C;T 30% T;T 2%
  • TuscanC;C 22% C;T 40% T;T 38%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3003609 is a SNP in the dynamin 1 DNM1 gene. The (T) allele of rs3003609 is associated with heavier smoking and thus nicotine dependence, at least in Caucasians though perhaps not African-Americans, based on a study of 600+ families.

Source and license

Adapted from rs3003609 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.