rs3027172
A SNP in the PER1 gene on chromosome 17. Its most notable genotype is G;G: Associated with alcohol dependence and increased drinking in response to psychosocial stress.
- Gene
- PER1
- Location
- Chr 178,152,405 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe
- Minor allele frequency
- 14%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs3027172 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Show notes, about 230 words
G;G
Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. (2011) ncbi.nlm.nih.gov Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an environmental risk factor for alcohol abuse. Circadian rhythm gene period 1 (Per1) is targeted by stress hormones and is transcriptionally activated in corticotropin releasing factor-expressing cells. mPer1-mutant mice showed enhanced alcohol consumption in response to social defeat stress relative to their wild-type littermates. An association with the frequency of heavy drinking in adolescents with the hPer1 promoter SNP rs3027172 and with psychosocial adversity was found. There was significant interaction between the rs3027172 genotype and psychosocial adversity on this drinking measure. Association of hPer1 rs3027172 with alcohol dependence was shown. Cortisol-induced transcriptional activation of hPer1 was reduced in human B-lymphoblastoid cells carrying the risk genotype of rs3027172. Binding affinity of the transcription factor Snail1 to the risk allele of the hPer1 SNP rs3027172 was also reduced. The findings indicate that the hPer1 gene regulates alcohol drinking behavior during stressful conditions and provide evidence for underlying neurobiological mechanisms.
Source and license
Adapted from rs3027172 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.