rs3077

A SNP in the HLA-DPA1 gene on chromosome 6. Its most notable genotype is G;G: 1.8 times higher odds of having chronic hepatitis B

Gene
HLA-DPA1
Location
Chr 633,065,245 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
40%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.8 times higher odds of having chronic hepatitis BWorth knowing · 2.024% of people
  2. A;AGoodcommon in complete genomicsTypical · 0.036% of people

SNPedia records rs3077 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 24% A;A 36%
  • European ancestry (Utah)G;G 4% A;A 73%
  • Han Chinese (Beijing)G;G 36% A;A 10%
  • Japanese (Tokyo)G;G 43% A;A 21%
  • Yoruba (Nigeria)G;G 54% A;A 8%
  • African ancestry (Southwest US)G;G 23% A;A 30%
  • Chinese (Denver)G;G 48% A;A 9%
  • Gujarati IndianG;G 14% A;A 43%
  • Luhya (Kenya)G;G 23% A;A 33%
  • Mexican ancestry (Los Angeles)G;G 3% A;A 62%
  • Maasai (Kenya)G;G 8% A;A 47%
  • TuscanG;G 5% A;A 61%

Other HLA-DPA1 SNPs

All HLA-DPA1 SNPs

Notes

From SNPedia

Notes

23andMe blog rs3077(A) and rs9277535(A) may reduce risk of Hepatitis B infection The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data. Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment. A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.

G;G

1.8 times higher odds of having chronic hepatitis B

A;A

lower risk of hepatitis B

Source and license

Adapted from rs3077 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.