rs3114018

A SNP in the ABCG2 gene on chromosome 4. Its most notable genotype is A;C: Somewhat higher risk for gout among Chinese

Gene
ABCG2
Location
Chr 488,143,429 (GRCh38)
Highest magnitude
2.3Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.028% of people
  2. A;CMost notableBadSomewhat higher risk for gout among ChineseWorth knowing · 2.345% of people
  3. C;CBadSomewhat higher risk for gout among ChineseWorth knowing · 2.327% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 28% A;C 45% C;C 27%
  • European ancestry (Utah)A;A 28% A;C 47% C;C 25%
  • Han Chinese (Beijing)A;A 13% A;C 51% C;C 36%
  • Japanese (Tokyo)A;A 4% A;C 40% C;C 56%
  • Yoruba (Nigeria)A;A 52% A;C 35% C;C 13%
  • African ancestry (Southwest US)A;A 40% A;C 51% C;C 9%
  • Chinese (Denver)A;A 19% A;C 42% C;C 39%
  • Gujarati IndianA;A 20% A;C 47% C;C 34%
  • Luhya (Kenya)A;A 47% A;C 43% C;C 10%
  • Mexican ancestry (Los Angeles)A;A 12% A;C 45% C;C 43%
  • Maasai (Kenya)A;A 35% A;C 49% C;C 16%
  • TuscanA;A 34% A;C 44% C;C 22%

Conditions, medicines and genes

Other ABCG2 SNPs

All ABCG2 SNPs

Notes

From SNPedia

Notes

rs3114018(C), a variant in the ABCG2 gene, was the most significantly associated with gout in a 2017 study of ~200 Han Chinese patients (OR 3.19, CI:2.24–4.55, p=6.1x10e-11). This study also defined 5 haplotype blocks associated with gout.

A;C

see text on main rs-page

C;C

see text on main rs-page

Source and license

Adapted from rs3114018 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.