rs3125923

A SNP on chromosome 1. Its most notable genotype is G;G: slightly (1.8x) increased risk for Taxane-induced peripheral neuropathy

Gene
None listed
Location
Chr 168,392,796 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.039% of people
  2. A;GBadslightly (50%) increased risk for Taxane-induced peripheral neuropathyMinor · 1.545% of people
  3. G;GMost notableBadslightly (1.8x) increased risk for Taxane-induced peripheral neuropathyWorth knowing · 2.015% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 39% A;G 45% G;G 15%
  • European ancestry (Utah)A;A 69% A;G 29% G;G 2%
  • Han Chinese (Beijing)A;A 27% A;G 56% G;G 18%
  • Japanese (Tokyo)A;A 16% A;G 61% G;G 23%
  • Yoruba (Nigeria)A;A 23% A;G 54% G;G 24%
  • African ancestry (Southwest US)A;A 35% A;G 51% G;G 14%
  • Chinese (Denver)A;A 33% A;G 48% G;G 20%
  • Gujarati IndianA;A 42% A;G 42% G;G 16%
  • Luhya (Kenya)A;A 24% A;G 52% G;G 23%
  • Mexican ancestry (Los Angeles)A;A 53% A;G 33% G;G 14%
  • Maasai (Kenya)A;A 33% A;G 54% G;G 13%
  • TuscanA;A 78% A;G 20% G;G 3%

Notes

From SNPedia

Notes

A;G

Slightly (50%) increased risk for peripheral neuropathy in patients undergoing chemotherapeutic treatment involving Taxane

G;G

Slightly (1.8x) increased risk for peripheral neuropathy in patients undergoing chemotherapeutic treatment involving Taxane

Source and license

Adapted from rs3125923 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.