rs3200254
A SNP in the ALPL gene on chromosome 1. Its most notable genotype is T;T: common in clinvar
- Gene
- ALPL
- Location
- Chr 121,568,242 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
- Minor allele frequency
- 28%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 52%
- European ancestry (Utah)T;T 77%
- Han Chinese (Beijing)T;T 29%
- Japanese (Tokyo)T;T 16%
- Yoruba (Nigeria)T;T 49%
- African ancestry (Southwest US)T;T 54%
- Chinese (Denver)T;T 26%
- Gujarati IndianT;T 66%
- Luhya (Kenya)T;T 58%
- Mexican ancestry (Los Angeles)T;T 52%
- Maasai (Kenya)T;T 69%
- TuscanT;T 79%
Related
Other ALPL SNPs
- i5002757A;AhypophosphatasiaVery important
- i5002758T;ThypophosphatasiaVery important
- i5002765C;ChypophosphatasiaVery important
- i5002766A;AhypophosphatasiaVery important
- i5002769C;ChypophosphatasiaVery important
- i5002770T;ThypophosphatasiaVery important
- i5002771C;ChypophosphatasiaVery important
- i5002772C;ChypophosphatasiaVery important
Notes
From SNPedia
Notes
Association of a TNAP haplotype with ankylosing spondylitis. No significant association between genetic polymorphisms in the TNAP gene and ankylosing spondylitis in the Chinese Han population. Mild forms of hypophosphatasia mostly result from dominant negative effect of severe alleles or from compound heterozygosity for severe and moderate alleles.
Source and license
Adapted from rs3200254 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.