rs324650

A SNP in the CHRM2 gene on chromosome 7. Its most notable genotype is A;T.

Gene
CHRM2
Location
Chr 7137,008,914 (GRCh38)
Highest magnitude
0.1Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.026% of people
  2. A;TMost notableNot ratedNo summary available.Typical · 0.136% of people
  3. T;TNot ratedNo summary available.Typical · 0.138% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 26% A;T 36% T;T 38%
  • European ancestry (Utah)A;A 28% A;T 48% T;T 24%
  • Han Chinese (Beijing)A;A 0% A;T 15% T;T 85%
  • Japanese (Tokyo)A;A 2% A;T 21% T;T 77%
  • Yoruba (Nigeria)A;A 56% A;T 38% T;T 6%
  • African ancestry (Southwest US)A;A 47% A;T 46% T;T 7%
  • Chinese (Denver)A;A 0% A;T 11% T;T 89%
  • Gujarati IndianA;A 5% A;T 37% T;T 58%
  • Luhya (Kenya)A;A 56% A;T 38% T;T 6%
  • Mexican ancestry (Los Angeles)A;A 16% A;T 45% T;T 40%
  • Maasai (Kenya)A;A 52% A;T 41% T;T 7%
  • TuscanA;A 26% A;T 54% T;T 21%

Other CHRM2 SNPs

All CHRM2 SNPs

Notes

From SNPedia

Show notes, about 230 words

In 2009, a large, multi-sample replication study failed to find any significant association with Intelligence for this or other SNPs in CHRM2 . Earlier work had observed that this snp (and perhaps its neighbors) influenced intelligence and alcohol dependence CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. And the earlier and or this pdf poster show association between the CHRM2 gene and intelligence . In this study of ~300 Caucasians, the (T;T) genotype appeared to typically have a 4 point higher IQ than the (A;T) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, rs324640, showed similar results to rs324650, and was in linkage disequilibrium (r2 = 0.90) with it. . No evidence for association between 19 cholinergic genes and bipolar disorder. Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study. Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

Source and license

Adapted from rs324650 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.