rs326

A SNP in the LPL gene on chromosome 8. Its most notable genotype is A;A: lower HDL cholesterol

Gene
LPL
Location
Chr 819,961,928 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadlower HDL cholesterolWorth knowing · 2.044% of people
  2. A;GNot ratedlower HDL cholesterolTypical · 0.039% of people
  3. G;GNot ratednormal riskTypical · 0.017% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 44% A;G 39% G;G 17%
  • European ancestry (Utah)A;A 53% A;G 35% G;G 12%
  • Han Chinese (Beijing)A;A 66% A;G 31% G;G 3%
  • Japanese (Tokyo)A;A 66% A;G 27% G;G 7%
  • Yoruba (Nigeria)A;A 16% A;G 42% G;G 42%
  • African ancestry (Southwest US)A;A 28% A;G 54% G;G 18%
  • Chinese (Denver)A;A 62% A;G 33% G;G 6%
  • Gujarati IndianA;A 66% A;G 32% G;G 2%
  • Luhya (Kenya)A;A 16% A;G 40% G;G 44%
  • Mexican ancestry (Los Angeles)A;A 52% A;G 36% G;G 12%
  • Maasai (Kenya)A;A 16% A;G 52% G;G 32%
  • TuscanA;A 44% A;G 41% G;G 15%

Other LPL SNPs

All LPL SNPs

Notes

From SNPedia

Notes

The (A) allele of rs326 was associated with risk for lower high-density lipoprotein (HDL) cholesterol plasma levels in 3 independent population samples, including both Caucasians and African-Americans.

Source and license

Adapted from rs326 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.