rs334354

A SNP in the TGFBR1 gene on chromosome 9. Its most notable genotype is A;A: Associated with cancer risk, but controversial

Gene
TGFBR1
Location
Chr 999,146,633 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadAssociated with cancer risk, but controversialTypical · 0.08% of people
  2. G;GGoodcommon in clinvarTypical · 0.050% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 8% G;G 50%
  • European ancestry (Utah)A;A 2% G;G 61%
  • Han Chinese (Beijing)A;A 21% G;G 35%
  • Japanese (Tokyo)A;A 20% G;G 26%
  • Yoruba (Nigeria)A;A 3% G;G 63%
  • African ancestry (Southwest US)A;A 4% G;G 51%
  • Chinese (Denver)A;A 10% G;G 36%
  • Gujarati IndianA;A 4% G;G 59%
  • Luhya (Kenya)A;A 12% G;G 53%
  • Mexican ancestry (Los Angeles)A;A 4% G;G 55%
  • Maasai (Kenya)A;A 11% G;G 46%
  • TuscanA;A 2% G;G 63%

Other TGFBR1 SNPs

All TGFBR1 SNPs

Notes

From SNPedia

Notes

A;A

rs334354 A allele is associated with a higher cancer risk, however even this study to confirm this association believes it will require more study ncbi.nlm.nih.gov

Source and license

Adapted from rs334354 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.