rs334558

A SNP in the LOC107986119 gene on chromosome 3. Its most notable genotype is A;A: later onset of BP

Gene
LOC107986119
Location
Chr 3120,094,435 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedlater onset of BPTypical · 0.04% of people
  2. A;GNot ratedlater onset of BPTypical · 0.029% of people
  3. G;GNot ratedcommonTypical · 0.067% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageA;A 4% A;G 29% G;G 67%
  • Han Chinese (Beijing)A;A 0% A;G 61% G;G 40%
  • Japanese (Tokyo)A;A 11% A;G 26% G;G 63%
  • Yoruba (Nigeria)A;A 0% A;G 2% G;G 98%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Although not associated with increased risk for developing bipolar disorder, amongst those with it, the (G) allele of this SNP has been reported to have a somewhat protective effect in that individuals who have a (G) allele develop bipolar disorder at a later age than those with the more common (A;A) genotypes. PMID 15351432, PMID 14729229 Also known as the -50T/C SNP from this GSK3-beta (GSK3B) gene. may effect lithium treatment response - C allele carriers showed considerably greater response with lithium treatment, with remissions of 56.25% after 4 weeks compared to 31% for T/T carriers

Source and license

Adapted from rs334558 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.