rs33950507
A SNP in the HBB gene on chromosome 11. Its most notable genotype is T;T: reduction in malarial risk; mild anemia
- Gene
- HBB
- Location
- Chr 115,226,943 (GRCh38)
- Highest magnitude
- 4.5Very important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadreduction in malarial risk; mild anemia
- C;TNot ratedreduction in malarial risk; carrier of beta thalassemia mutation
- C;CGoodnormal
SNPedia records rs33950507 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other HBB SNPs
- rs11549407A;ABeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33945777T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33960103G;GBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33971440T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33974936T;TBeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33986703A;ABeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34716011T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34889882-;-Beta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
Notes
From SNPedia
Notes
rs33950507 is a SNP found in the beta hemoglobin HBB gene, not far from the well-known SNP associated with malarial resistance (rs334, Hb S). This SNP gives rise to the "Hb E", or hemoglobin E, form of hemoglobin as the HBB forms are commonly named. It is found primarily in Southeast Asia. rs33950507(A) is associated with somewhat increased malarial resistance, and in homozygous (A;A) state, with mild hypochromic microcytic anemia. Microarray-based estimation of SNP allele-frequency in pooled DNA using the Langmuir kinetic model.
T;T
see HBB
C;T
see HBB
Source and license
Adapted from rs33950507 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.