rs33956879
A SNP in the HBB gene on chromosome 11. Its most notable genotype is A;A: common in clinvar
- Gene
- HBB
- Location
- Chr 115,226,928 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs33956879 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other HBB SNPs
- rs11549407A;ABeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33945777T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33960103G;GBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33971440T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33974936T;TBeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33986703A;ABeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34716011T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34889882-;-Beta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
Notes
From SNPedia
Notes
A new mutation at IVS1 nt 2(T----A), in beta-thalassemia from Algeria. Severe Hb S-beta zero-thalassaemia with a T----C substitution in the donor splice site of the first intron of the beta-globin gene. An African origin for an "American black" beta zero-thalassemia mutation? Intrinsic differences between authentic and cryptic 5' splice sites. Real-time PCR for single-cell genotyping in sickle cell and thalassemia syndromes as a rapid, accurate, reliable, and widely applicable protocol for preimplantation genetic diagnosis. Mutation analysis of the HBB gene in selected Bangladeshi beta-thalassemic individuals: presence of rare mutations.
Source and license
Adapted from rs33956879 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.