rs33977706

A SNP in the LOC105371082 gene on chromosome 16. Its most notable genotype is A;A: Lower body mass index

Gene
LOC105371082
Location
Chr 1611,256,298 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodLower body mass indexWorth knowing · 2.0

SNPedia records rs33977706 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LOC105371082 SNPs

All LOC105371082 SNPs

Notes

From SNPedia

Notes

rs33977706, also known as -820G>T, is a SNP in the promoter region of the suppressor of cytokine signalling 1 SOCS1 gene. This SNP has been reported to be associated with body mass index and obesity.

A;A

The rs33977706 polymorphism (-820G > T) was associated with a lower body mass index (BMI) (p = 0.004). In a second study (n = 4625 NGT subjects), significant associations of both the rs33977706 and the rs243330 (-1656G > A) variants to obesity were found (p = 0.047 and p = 0.015) respectively. PMID 19215277

References

Source and license

Adapted from rs33977706 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.