rs34330

A SNP in the GPR19 gene on chromosome 12. Its most notable genotype is C;T: 1.3x higher risk for endometrial cancer (in Chinese women)

Gene
GPR19
Location
Chr 1212,717,761 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormal risk for endometrial/breast cancerTypical · 0.043% of people
  2. C;TMost notableBad1.3x higher risk for endometrial cancer (in Chinese women)Minor · 1.344% of people
  3. C;TNot ratedNo summary available.Typical · 0.044% of people
  4. T;TBad1.2x higher breast cancer risk; 1.3x higher risk for endometrial cancer (in Chinese women)Minor · 1.313% of people

On SNPedia: (C;C), (C;T), (T;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 43% C;T 44% C;T 44% T;T 13%
  • European ancestry (Utah)C;C 55% C;T 39% C;T 39% T;T 6%
  • Han Chinese (Beijing)C;C 28% C;T 50% C;T 50% T;T 22%
  • Japanese (Tokyo)C;C 24% C;T 50% C;T 50% T;T 26%
  • Yoruba (Nigeria)C;C 31% C;T 52% C;T 52% T;T 18%
  • African ancestry (Southwest US)C;C 41% C;T 43% C;T 43% T;T 16%
  • Chinese (Denver)C;C 33% C;T 48% C;T 48% T;T 19%
  • Gujarati IndianC;C 64% C;T 28% C;T 28% T;T 8%
  • Luhya (Kenya)C;C 26% C;T 59% C;T 59% T;T 15%
  • Mexican ancestry (Los Angeles)C;C 64% C;T 29% C;T 29% T;T 7%
  • Maasai (Kenya)C;C 48% C;T 46% C;T 46% T;T 6%
  • TuscanC;C 56% C;T 39% C;T 39% T;T 5%

Conditions, medicines and genes

Other GPR19 SNPs

All GPR19 SNPs

Notes

From SNPedia

Notes

Category:interestingrs34330 shows an association with breast cancer in a British study involving ~2300 patients. The odds ratio for the (T;T) vs (C;C) homozygotes is 1.22 (CI: 1.02-1.47, p=0.013). found a significant association between rs34330 (-79C/T) and prostate cancer found higher odds for endometrial cancer among 1,200+ Chinese patients associated with rs34330, with an odds ratio of 1.33 (CI: 1.06-1.66) and 1.51 (CI: 1.16-1.94) for the (C;T) and (T;T) genotypes, respectively, compared with the (C;C) genotype. see also omim 176807

Source and license

Adapted from rs34330 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.