rs34536443
A SNP in the TYK2 gene on chromosome 19. Its most notable genotype is C;C: Much higher (90 fold) risk of developing tuberculosis if exposed to TB bacterium
- Gene
- TYK2
- Location
- Chr 1910,352,442 (GRCh38)
- Highest magnitude
- 6.3Very important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadMuch higher (90 fold) risk of developing tuberculosis if exposed to TB bacterium
- C;GBadCarrier of a tuberculosis susceptibility mutation
- G;GGoodcommon in complete genomics
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
aka c.3310C>G (p.Pro1104Ala or P1104A) Inherited recessively, this variant appears to greatly increase (OR 89.3, CI: 14.7 - 1725, p=8.3x10e-8) the risk of developing tuberculosis according to a 2018 study, if the carrier of the minor homozygote genotype is exposed to the tuberculosis mycobacterium. The mechanism by which this occurs led to the suggestion that at-risk individuals could potentially prevent or treat the disease with gamma-interferon. In Europeans, one in 600 people have two copies of the rs10352442(C) variant (which is the c.3310(G) variant), and in the rest of the world, the rate is estimated to be between one in 1,000 to one in 10,000.futurity.org
C;C
See discussion on main rs-page.
C;G
Unaffected in absence of a second TYK2 gene mutation; see discussion on main rs-page.
Source and license
Adapted from rs34536443 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.