rs34677591

A SNP in the SDHD gene on chromosome 11. Its most notable genotype is A;G: either just a polymorphism, or, a slight cancer predisposing mutation

Gene
SDHD
Location
Chr 11112,086,941 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableBadeither just a polymorphism, or, a slight cancer predisposing mutationWorth knowing · 2.0
  2. G;GGoodcommon in clinvarTypical · 0.0

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SDHD SNPs

All SDHD SNPs

Notes

From SNPedia

Show notes, about 120 words

rs34677591, also known as c.34G>A, p.Gly12Ser and G12S, is a SNP in the SDHD gene on chromosome 11. Defining the effect of this SNP has been difficult, and different investigators have come to different conclusions. In summary, the rare rs34677591(A) allele is either a a low-penetrance mutation or a rare polymorphism. The cancers most often mentioned in association with G12S are paragangliomas and pheochromocytomas. The G12S mutation has also been associated with increased manganese superoxide dismutase expression. For a good summary of the studies involved, see OMIM 602690.0011.

A;G

The rare A allele is either a benign polymorphism, or it is a mutation predisposing some individuals to some cancers. See discussion at rs34677591.

Source and license

Adapted from rs34677591 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.