rs351855(A;A)

2x increased prostate cancer risk; among breast cancer patients, herceptin is less effective

Magnitude
2.9Worth knowing
Repute
Bad
Frequency
9%Average of 4 populations
On SNPedia
rs351855(T;T)Minus strand
Gene
FGFR4

Frequency

Share of people with A;A in each HapMap population.

  • Han Chinese (Beijing)17%
  • Japanese (Tokyo)15%
  • European ancestry (Utah)3%
  • Yoruba (Nigeria)0%

Other genotypes of rs351855

  1. G;GGoodnormalTypical · 0.044% of people
  2. A;GBad1.2x increased risk for prostate cancerWorth knowing · 2.047% of people

All about rs351855

Notes

From SNPedia

This SNP is part of several polygenic risk scores for breast cancer, so in that sense it's "valid" but as a stand-alone SNP it's not of much clinical consequence. This rare genotype of the fibroblast growth factor receptor 4 gene influences several forms of cancer progression and tumor cell motility. It is found in ~3% of people. It is unlikely that any clinician person would take any action on this alone. As a risk factor for breast or prostate cancer in people with Asian ancestry, it seems to increase risk by ~ 1.2x.

Source and license

Adapted from rs351855(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.