rs35705950

A SNP on chromosome 11. Its most notable genotype is T;T: Significantly higher (>10x) risk for lung issues (fibrosis or pneumonia)

Gene
None listed
Location
Chr 111,219,991 (GRCh38)
Highest magnitude
5.8Very important
Tested on
AncestryDNA
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in complete genomicsTypical · 0.0
  2. G;TBadPossible miscall in Ancestry v2d data; otherwise, moderately (>5x) higher risk for lung issues (fibrosis or pneumonia)Very important · 4.4
  3. T;TMost notableBadSignificantly higher (>10x) risk for lung issues (fibrosis or pneumonia)Very important · 5.8

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs35705950 is a SNP located 3 kb upstream of the start of transcription from the mucin 5B MUC5B gene. Two independent research groups both published articles in April 2011 associating the minor (T) allele of rs35705950 with highly increased risk for interstitial pneumonia and/or pulmonary fibrosis. For interstitial pneumonia, the odds ratio for heterozygotes was 6.8 (CI: 3.9 - 12.0) and for homozygotes, 20.8 (CI: 3.8 - 113.7). For pulmonary fibrosis, the reported odds ratios for heterozygotes and homozygotes in one study were 9.0 (CI: 6.2 to 13.1) and 21.8 (CI: 5.1 to 93.5), respectively, and were 5.9 (CI: 4.4 - 7.8) and 9.7 (CI: 4.7 - 19.9) in the other.

G;T

See discussion via main rs-page.

T;T

See discussion via main rs-page

Source and license

Adapted from rs35705950 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.