rs36210423

A SNP in the SCN5A gene on chromosome 3. Its most notable genotype is T;T: likely to be benign

Gene
SCN5A
Location
Chr 338,603,887 (GRCh38)
Highest magnitude
0.5Typical
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodlikely to be benignTypical · 0.5
  2. G;TGoodlikely to be benignTypical · 0.5
  3. G;GGoodcommon in clinvarTypical · 0.0

SNPedia records rs36210423 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SCN5A SNPs

All SCN5A SNPs

Notes

From SNPedia

Show notes, about 120 words

rs36210423 is a variant in the SCN5A gene on chromosome 3. The major allele (on the minus strand) is C; all three possible minor alleles (A,G,T) have apparently been reported as occurring, according to dbSNP. The three minor alleles and their more common protein designations are: * c.1715C>A, Ala572Asp or A527D * c.1715C>T, Ala572Val or A572D * c.1715C>G, Ala572Gly or A572G Most reports of pathogenicity (or the lack of it) focus on A572D, which was initially reported as a pathogenic (and dominant) mutation potentially leading to a mild form of long QT syndrome.. Subsequent analyses by several groups have tended to conclude that all rs36210423 variants are likely to be benign.

T;T

see discussion at rs36210423

G;T

see discussion at rs36210423

Source and license

Adapted from rs36210423 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.