rs362344
A SNP in the PSEN1 gene on chromosome 14. Its most notable genotype is C;C: common in clinvar
- Gene
- PSEN1
- Location
- Chr 1473,223,011 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 47%
- European ancestry (Utah)C;C 61%
- Han Chinese (Beijing)C;C 34%
- Japanese (Tokyo)C;C 27%
- Yoruba (Nigeria)C;C 46%
- African ancestry (Southwest US)C;C 54%
- Chinese (Denver)C;C 36%
- Gujarati IndianC;C 64%
- Luhya (Kenya)C;C 43%
- Mexican ancestry (Los Angeles)C;C 43%
- Maasai (Kenya)C;C 44%
- TuscanC;C 61%
Related
Other PSEN1 SNPs
- rs661A;Aearly onset Alzheimer's diseaseVery important
- rs63749885C;Tearly-onset Alzheimers diseaseVery important
- rs63749891C;Gearly-onset Alzheimers diseaseVery important
- rs63750577C;Tearly-onset Alzheimers diseaseVery important
- rs63750599C;Tearly-onset Alzheimers diseaseVery important
- rs63750815G;Tearly-onset Alzheimers diseaseVery important
- rs63750886C;Gearly-onset Alzheimers diseaseVery important
- rs63750900A;Gearly-onset Alzheimers diseaseVery important
Source and license
Adapted from rs362344 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.