rs364048
A SNP in the APP gene on chromosome 21. Its most notable genotype is T;T: common genotype
- Gene
- APP
- Location
- Chr 2126,171,723 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 73%
- European ancestry (Utah)T;T 96%
- Han Chinese (Beijing)T;T 64%
- Japanese (Tokyo)T;T 55%
- Yoruba (Nigeria)T;T 61%
- African ancestry (Southwest US)T;T 72%
- Chinese (Denver)T;T 64%
- Gujarati IndianT;T 92%
- Luhya (Kenya)T;T 56%
- Mexican ancestry (Los Angeles)T;T 81%
- Maasai (Kenya)T;T 67%
- TuscanT;T 95%
Related
Other APP SNPs
- rs63750973A;GConsidered pathogenic for an early-onset form of Alzheimer's diseaseVery important
- rs281865161GA;TCAlzheimer's disease, familialVery important
- rs63749810C;TEarly-onset Alzheimer's diseaseVery important
- rs63749964A;CLikely miscall in 23andMe v4 data; otherwise, Alzheimer's disease pathogenic mutationVery important
- rs63750066C;TEarly-onset Alzheimer's diseaseVery important
- rs63750151C;GAlzheimer's diseaseVery important
- rs63750264C;TAlzheimer's disease mutationVery important
- rs63750399C;TMutation considered pathogenic for Alzheimer diseaseVery important
Source and license
Adapted from rs364048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.