rs373863828
A SNP in the CREBRF gene on chromosome 5. Its most notable genotype is A;G: 1.35x increased obesity risk, at least for Samoans
- Gene
- CREBRF
- Location
- Chr 5173,108,771 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 130 words
A thrifty variant in CREBRF strongly influences body mass index in Samoans (rs12513649 and rs373863828). The key finding is that rs373863828(A) is associated with a 35 per cent higher chance of obesity (i.e. odds ratio of 1.35), and this rare variant is far more common among Samoans than Africans, Europeans or East Asians. However, since the frequency of this variant in Samoans is unlikely to have changed dramatically over the last 200 years, whereas the obesity rare in this population has increased dramatically, the variant on it's own is considered insufficient to lead to obesity. Instead, the change in diet and in other environmental factors (less exercise, for example) is likely to act in synergy with this variant to lead to increased risk for obesity.
A;G
see discussion at rs373863828
Source and license
Adapted from rs373863828 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.