rs3741049

A SNP in the ACAT1 gene on chromosome 11. Its most notable genotype is G;G.

Gene
ACAT1
Location
Chr 11108,139,200 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodNo summary available.Typical · 0.073% of people

SNPedia records rs3741049 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 73%
  • European ancestry (Utah)G;G 67%
  • Han Chinese (Beijing)G;G 40%
  • Japanese (Tokyo)G;G 41%
  • Yoruba (Nigeria)G;G 97%
  • African ancestry (Southwest US)G;G 91%
  • Chinese (Denver)G;G 47%
  • Gujarati IndianG;G 74%
  • Luhya (Kenya)G;G 97%
  • Mexican ancestry (Los Angeles)G;G 67%
  • Maasai (Kenya)G;G 95%
  • TuscanG;G 84%

Notes

From SNPedia

Notes

Plays a major role in ketone body metabolism. Defects cause a 3-ketothiolase deficiency. Yasko believes it will cause an increase in gut bugs (particularly clostridia) as well as elevated fatty acid metabolites. This is one of the SNPs reported by NutraHacker.

Source and license

Adapted from rs3741049 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.