rs3745274(T;T)

If efavirenz is ever prescribed for you, lower doses may be advisable

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
9%Average of 11 populations
On SNPedia
rs3745274(T;T)
Gene
CYP2B6

Frequency

Share of people with T;T in each HapMap population.

  • Gujarati Indian20%
  • Yoruba (Nigeria)18%
  • Maasai (Kenya)13%
  • Luhya (Kenya)13%
  • Tuscan9%
  • European ancestry (Utah)7%
  • African ancestry (Southwest US)7%
  • Japanese (Tokyo)6%
  • Han Chinese (Beijing)4%
  • Mexican ancestry (Los Angeles)3%
  • Chinese (Denver)3%

Other genotypes of rs3745274

  1. G;GGoodcommon in clinvarTypical · 0.051% of people

All about rs3745274

Notes

From SNPedia

see rs3745274; poor metabolizer of efavirenz may cause CNS toxicity if given normal doses as part of HIV treatment regimen

Source and license

Adapted from rs3745274(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.