rs3746444

A SNP in the LOC107985393 gene on chromosome 20. Its most notable genotype is G;G: ~1.2x increased risk for cancer

Gene
LOC107985393
Location
Chr 2034,990,448 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad~1.2x increased risk for cancerWorth knowing · 2.1
  2. A;GBad~1.2x increased risk for cancerWorth knowing · 2.0
  3. A;AGooddecreased cancer riskWorth knowing · 2.1

SNPedia records rs3746444 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other LOC107985393 SNPs

All LOC107985393 SNPs

Notes

From SNPedia

Show notes, about 290 words

microRNA 1,009 breast cancer cases and 1,093 controls in a population of Chinese women *rs3746444 in hsa-mir-499 A>G OR 1.25; 95% CI, 1.02-1.51 Genetic variants of miRNA sequences and non-small cell lung cancer survival. Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes. SNPs in human miRNA genes affect biogenesis and function. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. MicroRNA polymorphisms: a giant leap towards personalized medicine. Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus. Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population. Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma. Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India. Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population. Association between two single nucleotide polymorphisms at corresponding microRNA and schizophrenia in a Chinese population. Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers. Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population. Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease. Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population.

A;A

source

References

Source and license

Adapted from rs3746444 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.