rs3749172

A SNP in the GPR35 gene on chromosome 2. Its most notable genotype is A;A: >1.45x Increased risk for Crohn's disease in Koreans

Gene
GPR35
Location
Chr 2240,630,832 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad>1.45x Increased risk for Crohn's disease in KoreansTypical · 0.033% of people
  2. A;CBad1.45x Increased risk for Crohn's disease in KoreansTypical · 0.040% of people
  3. C;CGoodnormal risk of Crohn's diseaseTypical · 0.027% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 33% A;C 40% C;C 27%
  • European ancestry (Utah)A;A 23% A;C 47% C;C 31%
  • Han Chinese (Beijing)A;A 10% A;C 48% C;C 42%
  • Japanese (Tokyo)A;A 6% A;C 38% C;C 56%
  • Yoruba (Nigeria)A;A 71% A;C 26% C;C 3%
  • African ancestry (Southwest US)A;A 47% A;C 44% C;C 9%
  • Chinese (Denver)A;A 9% A;C 49% C;C 42%
  • Gujarati IndianA;A 2% A;C 35% C;C 63%
  • Luhya (Kenya)A;A 67% A;C 33% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 37% A;C 40% C;C 23%
  • Maasai (Kenya)A;A 66% A;C 32% C;C 3%
  • TuscanA;A 19% A;C 51% C;C 31%

Notes

From SNPedia

Notes

Implicated in a 2015 Korean cohort for Crohn's disease. PMID 25489960

Source and license

Adapted from rs3749172 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.