rs3749977

A SNP in the LOC105375003 gene on chromosome 6. Its most notable genotype is G;G: common (highest ability to smell cut grass)

Gene
LOC105375003
Location
Chr 629,112,567 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedcommon (highest ability to smell cut grass)Minor · 1.037% of people
  2. A;GNot ratedlower ability to smell cut grassMinor · 1.043% of people
  3. A;ANot ratedlowest ability to smell cut grassMinor · 1.020% of people

SNPedia records rs3749977 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 37% A;G 43% A;A 20%
  • European ancestry (Utah)G;G 55% A;G 36% A;A 9%
  • Han Chinese (Beijing)G;G 50% A;G 42% A;A 7%
  • Japanese (Tokyo)G;G 69% A;G 27% A;A 4%
  • Yoruba (Nigeria)G;G 12% A;G 54% A;A 34%
  • African ancestry (Southwest US)G;G 16% A;G 51% A;A 33%
  • Chinese (Denver)G;G 55% A;G 41% A;A 4%
  • Gujarati IndianG;G 29% A;G 48% A;A 24%
  • Luhya (Kenya)G;G 9% A;G 45% A;A 46%
  • Mexican ancestry (Los Angeles)G;G 43% A;G 52% A;A 5%
  • Maasai (Kenya)G;G 7% A;G 44% A;A 49%
  • TuscanG;G 58% A;G 36% A;A 6%

Notes

From SNPedia

Notes

rs3749977, also known as Arg226Gln, is a SNP in the olfactory receptor OR2J3 gene. The rarer allele is apparently always found with the rarer allele of rs28757581, according to . A study of 52 unrelated volunteers who were not anosmic tested their ability to detect cis-3-hexen-1-ol (C3HEX), a compound given off by "wounded" plants, most typically, cut grass. The rarer alleles of rs3749977 and rs28757581 were associated with a lowered ability to detect this smell.

Source and license

Adapted from rs3749977 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.