rs3750344

A SNP in the GABBR2 gene on chromosome 9. Its most notable genotype is T;T: common in complete genomics

Gene
GABBR2
Location
Chr 998,578,034 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in complete genomicsTypical · 0.067% of people

SNPedia records rs3750344 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 67%
  • European ancestry (Utah)T;T 67%
  • Han Chinese (Beijing)T;T 69%
  • Japanese (Tokyo)T;T 65%
  • Yoruba (Nigeria)T;T 48%
  • African ancestry (Southwest US)T;T 68%
  • Chinese (Denver)T;T 84%
  • Gujarati IndianT;T 75%
  • Luhya (Kenya)T;T 62%
  • Mexican ancestry (Los Angeles)T;T 85%
  • Maasai (Kenya)T;T 52%
  • TuscanT;T 66%

Conditions, medicines and genes

Other GABBR2 SNPs

All GABBR2 SNPs

Notes

From SNPedia

Notes

Associated with Nicotine Dependence as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans. Interestingly, the risk allele varies between populations. Among African-Americans, the haplotype C-C-G of rs2491397-rs2184026-rs3750344 had a significant positive association with nicotine dependence. Among European-Americans, for rs1435252-rs3780422-rs2779562-rs3750344, the C-A-C-A haplotype was positively associated with nicotine dependence while the T-A-T-A haplotype was negatively associated.

Source and license

Adapted from rs3750344 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.