rs3755351

A SNP in the ADD2 gene on chromosome 2. Its most notable genotype is T;T: >1.3x risk for hypertension

Gene
ADD2
Location
Chr 270,747,758 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot rated>1.3x risk for hypertensionTypical · 0.010% of people
  2. G;TBad1.3x risk for hypertensionTypical · 0.047% of people
  3. G;GNot ratednormalTypical · 0.043% of people

SNPedia records rs3755351 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 10% G;T 47% G;G 43%
  • European ancestry (Utah)T;T 12% G;T 45% G;G 43%
  • Han Chinese (Beijing)T;T 10% G;T 47% G;G 42%
  • Japanese (Tokyo)T;T 8% G;T 31% G;G 61%
  • Yoruba (Nigeria)T;T 14% G;T 48% G;G 38%
  • African ancestry (Southwest US)T;T 5% G;T 53% G;G 42%
  • Chinese (Denver)T;T 7% G;T 49% G;G 44%
  • Gujarati IndianT;T 7% G;T 42% G;G 52%
  • Luhya (Kenya)T;T 12% G;T 47% G;G 41%
  • Mexican ancestry (Los Angeles)T;T 10% G;T 48% G;G 41%
  • Maasai (Kenya)T;T 12% G;T 54% G;G 35%
  • TuscanT;T 16% G;T 51% G;G 33%

Notes

From SNPedia

Notes

rs3755351, a SNP in the ADD2 gene, was associated with risk for hypertension in a study involving 1,500+ Japanese patients. The odds ratio associated with the risk allele, rs3755351(C), which is also the most common allele, is 1.30 (CI: 1.15 - 1.46, p = 0.00002). Note that a neighboring ADD2 SNP in close (r2 of 0.806) proximity, rs17006246, was associated with hypertension in a diabetes study ; however, in this case, it was in "the opposite direction of effect". This discrepancy has not been resolved.

Source and license

Adapted from rs3755351 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.