rs3758650

A SNP in the CDHR5 gene on chromosome 11. Its most notable genotype is A;A: 6x increased risk for gallstone disease in Taiwanese/Chinese

Gene
CDHR5
Location
Chr 11616,865 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad6x increased risk for gallstone disease in Taiwanese/ChineseWorth knowing · 2.2<1% of people
  2. A;GNot rated1.6x increased risk for gallstone disease in Taiwanese/ChineseMinor · 1.612% of people
  3. G;GGoodcommon in complete genomicsTypical · 0.088% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A <1% A;G 12% G;G 88%
  • European ancestry (Utah)A;A 2% A;G 13% G;G 85%
  • Han Chinese (Beijing)A;A <1% A;G 17% G;G 83%
  • Japanese (Tokyo)A;A 0% A;G 13% G;G 87%
  • Yoruba (Nigeria)A;A 0% A;G 4% G;G 96%
  • Chinese (Denver)A;A <1% A;G 17% G;G 82%
  • Gujarati IndianA;A 3% A;G 26% G;G 71%
  • Luhya (Kenya)A;A 0% A;G 2% G;G 98%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 2% G;G 98%
  • Maasai (Kenya)A;A <1% A;G 17% G;G 82%
  • TuscanA;A 0% A;G 6% G;G 94%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3758650 is a SNP in the cadherin-related family member 5 CDHR5 gene. A study of 452 Taiwanese patients with gallstone disease found association between rs3758650 and risk for this disorder, with an odds ratio of 1.59 (adjusted p=0.013) for the rs3758650(A;G) genotype and 5.82 (adjusted p=0.007) for the rs3758650(A;A) genotype when compared with the reference (G;G) genotype.

A;A

but so far based only a single paper of small sample size

Source and license

Adapted from rs3758650 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.