rs3761218

A SNP in the CDC25B gene on chromosome 20. Its most notable genotype is A;G.

Gene
CDC25B
Location
Chr 203,795,528 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. C;CNot rated1.3x riskTypical · 0.011% of people
  3. C;TNot ratednormalTypical · 0.044% of people
  4. G;GNot ratedNo summary available.Typical · 0.00% of people
  5. T;TNot ratednormalTypical · 0.044% of people

On SNPedia: (A;G), (C;C), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;G 0% C;C 11% C;T 44% G;G 0% T;T 44%
  • European ancestry (Utah)A;G 0% C;C 20% C;T 51% G;G 0% T;T 29%
  • Han Chinese (Beijing)A;G 0% C;C 12% C;T 45% G;G 0% T;T 43%
  • Japanese (Tokyo)A;G 0% C;C 5% C;T 45% G;G 0% T;T 50%
  • Yoruba (Nigeria)A;G 0% C;C 4% C;T 34% G;G 0% T;T 62%
  • African ancestry (Southwest US)A;G 0% C;C 7% C;T 39% G;G 0% T;T 54%
  • Chinese (Denver)A;G 0% C;C 6% C;T 40% G;G 0% T;T 53%
  • Gujarati IndianA;G 0% C;C 28% C;T 49% G;G 0% T;T 24%
  • Luhya (Kenya)A;G 0% C;C 5% C;T 43% G;G 0% T;T 53%
  • Mexican ancestry (Los Angeles)A;G 0% C;C 16% C;T 41% G;G 0% T;T 43%
  • Maasai (Kenya)A;G 0% C;C 9% C;T 40% G;G 0% T;T 51%
  • TuscanA;G 0% C;C 15% C;T 59% G;G 0% T;T 27%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3761218 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 0.97 (CI 0.81-1.15), and for homozygotes, 1.31 (CI 1.09-1.57). Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.

Source and license

Adapted from rs3761218 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.