rs3761418

A SNP in the RSPH14 gene on chromosome 22. Its most notable genotype is A;A: 1.3x increased risk for depression

Gene
RSPH14
Location
Chr 2223,178,907 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.3x increased risk for depressionTypical · 0.047% of people
  2. A;GNot rated1.3x increased risk for depressionTypical · 0.043% of people
  3. G;GNot ratednormal riskTypical · 0.010% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 47% A;G 43% G;G 10%
  • European ancestry (Utah)A;A 50% A;G 40% G;G 10%
  • Han Chinese (Beijing)A;A 41% A;G 50% G;G 10%
  • Japanese (Tokyo)A;A 44% A;G 43% G;G 13%
  • Yoruba (Nigeria)A;A 37% A;G 47% G;G 16%
  • African ancestry (Southwest US)A;A 47% A;G 40% G;G 12%
  • Chinese (Denver)A;A 39% A;G 47% G;G 14%
  • Gujarati IndianA;A 69% A;G 29% G;G 2%
  • Luhya (Kenya)A;A 44% A;G 47% G;G 9%
  • Mexican ancestry (Los Angeles)A;A 36% A;G 53% G;G 10%
  • Maasai (Kenya)A;A 48% A;G 42% G;G 10%
  • TuscanA;A 62% A;G 32% G;G 6%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3761418, a SNP in the BCR gene on chromosome 22, has been associated with increased risk for depression. The odds ratio for carriers of the minor allele (G) are reported as 1.32 (p=0.012) based on a study of 329 Japanese patients.

Source and license

Adapted from rs3761418 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.