rs3764261

A SNP on chromosome 16. Its most notable genotype is A;A: associated with higher HDL cholesterol. HDL = good

Gene
None listed
Location
Chr 1656,959,412 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
27%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.051% of people
  2. A;CGoodassociated with higher HDL cholesterolWorth knowing · 2.040% of people
  3. A;AMost notableGoodassociated with higher HDL cholesterol. HDL = goodWorth knowing · 2.510% of people

SNPedia records rs3764261 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 51% A;C 40% A;A 10%
  • European ancestry (Utah)C;C 43% A;C 44% A;A 12%
  • Han Chinese (Beijing)C;C 68% A;C 29% A;A 2%
  • Japanese (Tokyo)C;C 64% A;C 30% A;A 6%
  • Yoruba (Nigeria)C;C 48% A;C 44% A;A 8%
  • African ancestry (Southwest US)C;C 47% A;C 39% A;A 14%
  • Chinese (Denver)C;C 71% A;C 28% A;A <1%
  • Gujarati IndianC;C 37% A;C 50% A;A 14%
  • Luhya (Kenya)C;C 37% A;C 47% A;A 17%
  • Mexican ancestry (Los Angeles)C;C 48% A;C 40% A;A 12%
  • Maasai (Kenya)C;C 42% A;C 47% A;A 11%
  • TuscanC;C 50% A;C 40% A;A 10%

Conditions, medicines and genes

Notes

From SNPedia

Notes

T allele is associated with 3.47mg/dl increase in HDL cholesterol (good cholesterol).

Source and license

Adapted from rs3764261 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.