rs3770748

A SNP in the QPCT gene on chromosome 2. Its most notable genotype is G;G: average risk?

Gene
QPCT
Location
Chr 237,368,382 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
27%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedaverage risk?Typical · 0.010% of people
  2. A;GNot rated1.26x risk for lower bone mineral densityTypical · 0.038% of people
  3. A;ANot ratedaverage risk?Typical · 0.052% of people

SNPedia records rs3770748 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 10% A;G 38% A;A 52%
  • European ancestry (Utah)G;G 3% A;G 23% A;A 74%
  • Han Chinese (Beijing)G;G 26% A;G 50% A;A 24%
  • Japanese (Tokyo)G;G 35% A;G 55% A;A 11%
  • Yoruba (Nigeria)G;G 2% A;G 41% A;A 57%
  • African ancestry (Southwest US)G;G 5% A;G 30% A;A 65%
  • Chinese (Denver)G;G 19% A;G 59% A;A 21%
  • Gujarati IndianG;G 9% A;G 38% A;A 54%
  • Luhya (Kenya)G;G 8% A;G 46% A;A 46%
  • Mexican ancestry (Los Angeles)G;G 2% A;G 28% A;A 71%
  • Maasai (Kenya)G;G 3% A;G 32% A;A 65%
  • TuscanG;G 0% A;G 21% A;A 79%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3770748, a SNP in an intron of the QPCT gene, was studied in a population of ~200 Chinese osteoporosis patients. Heterozygotes appeared to be at higher risk than either homozygote, and the association was statistically strongest in post-menopausal women. Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse.

Source and license

Adapted from rs3770748 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.