rs3781719

A SNP in the CALCA gene on chromosome 11. Its most notable genotype is G;G: 2x increased hypertension risk

Gene
CALCA
Location
Chr 1114,972,978 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
31%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated2x increased hypertension riskTypical · 0.012% of people
  2. A;GNot rated2x increased hypertension riskTypical · 0.042% of people
  3. A;ANot ratednormalTypical · 0.047% of people

SNPedia records rs3781719 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 12% A;G 42% A;A 47%
  • European ancestry (Utah)G;G 11% A;G 43% A;A 46%
  • Han Chinese (Beijing)G;G 2% A;G 23% A;A 75%
  • Japanese (Tokyo)G;G 8% A;G 41% A;A 51%
  • Yoruba (Nigeria)G;G 20% A;G 44% A;A 37%
  • African ancestry (Southwest US)G;G 18% A;G 39% A;A 44%
  • Chinese (Denver)G;G 3% A;G 27% A;A 71%
  • Gujarati IndianG;G 7% A;G 41% A;A 53%
  • Luhya (Kenya)G;G 19% A;G 49% A;A 32%
  • Mexican ancestry (Los Angeles)G;G 17% A;G 57% A;A 26%
  • Maasai (Kenya)G;G 17% A;G 55% A;A 28%
  • TuscanG;G 9% A;G 41% A;A 50%

Notes

From SNPedia

Notes

rs3781719 is a SNP, also known as T-692C, in the calcitonin-related polypeptide alpha CALCA gene. A study of 293 Chinese subjects with essential hypertension (EH) and 208 controls concluded that rs3781719(C) allele carriers were associated with increased EH risk (odds ratio 2.093, CI: 1.317-3.326, p<0.01).

Source and license

Adapted from rs3781719 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.