rs3782179

A SNP in the KITLG gene on chromosome 12. Its most notable genotype is C;C: 9x lower odds of testicular cancer

Gene
KITLG
Location
Chr 1288,559,549 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGood9x lower odds of testicular cancerWorth knowing · 2.527% of people
  2. C;TGood3x lower odds of testicular cancer risk for menWorth knowing · 2.034% of people
  3. T;TBadcommon, but increased risk of testicular cancerMinor · 1.539% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 27% C;T 34% T;T 39%
  • European ancestry (Utah)C;C 5% C;T 29% T;T 66%
  • Han Chinese (Beijing)C;C 6% C;T 47% T;T 47%
  • Japanese (Tokyo)C;C 25% C;T 48% T;T 27%
  • Yoruba (Nigeria)C;C 63% C;T 35% T;T 2%
  • African ancestry (Southwest US)C;C 61% C;T 33% T;T 5%
  • Chinese (Denver)C;C 5% C;T 36% T;T 60%
  • Gujarati IndianC;C 4% C;T 37% T;T 59%
  • Luhya (Kenya)C;C 69% C;T 28% T;T 4%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 24% T;T 74%
  • Maasai (Kenya)C;C 56% C;T 34% T;T 10%
  • TuscanC;C 2% C;T 25% T;T 73%

Conditions, medicines and genes

Other KITLG SNPs

All KITLG SNPs

Notes

From SNPedia

Notes

Testicular germ cell tumor risk I("TGCT"; i.e. testicular cancer risk) was increased 3x per copy of the major (T) allele at rs3782179 and rs4474514 (OR = 3.08, CI: 2.29–4.13; OR = 3.07, CI = 2.29–4.13, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the c-KIT ligand KITLG gene have a 4.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. https://www.23andme.com/you/community/thread/7837/ The original study was also only done in 277 people with the disease and 900 controls, so it's a very small study.

Source and license

Adapted from rs3782179 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.