rs3790565

A SNP in the IL12RB2 gene on chromosome 1. Its most notable genotype is C;C: Increased risk of developing primary biliary cirrhosis

Gene
IL12RB2
Location
Chr 167,345,673 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadIncreased risk of developing primary biliary cirrhosisWorth knowing · 2.021% of people
  2. C;TBadSlightly increased risk of developing primary biliary cirrhosisMinor · 1.535% of people
  3. T;TGoodNormal risk of developing primary biliary cirrhosisMinor · 1.045% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 21% C;T 35% T;T 45%
  • European ancestry (Utah)C;C <1% C;T 42% T;T 57%
  • Han Chinese (Beijing)C;C 5% C;T 30% T;T 65%
  • Japanese (Tokyo)C;C 3% C;T 35% T;T 63%
  • Yoruba (Nigeria)C;C 60% C;T 32% T;T 8%
  • African ancestry (Southwest US)C;C 32% C;T 52% T;T 16%
  • Chinese (Denver)C;C 5% C;T 30% T;T 65%
  • Gujarati IndianC;C 3% C;T 18% T;T 79%
  • Luhya (Kenya)C;C 64% C;T 30% T;T 7%
  • Mexican ancestry (Los Angeles)C;C 9% C;T 28% T;T 64%
  • Maasai (Kenya)C;C 38% C;T 52% T;T 11%
  • TuscanC;C 7% C;T 36% T;T 57%

Conditions, medicines and genes

Other IL12RB2 SNPs

All IL12RB2 SNPs

Notes

From SNPedia

Notes

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. C allele associated with increased risk of Primary biliary cirrhosis

Source and license

Adapted from rs3790565 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.