rs3794260

A SNP in the LOC105369965 gene on chromosome 12. Its most notable genotype is A;A: >1.26x risk for hypertension

Gene
LOC105369965
Location
Chr 12108,204,497 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad>1.26x risk for hypertensionTypical · 0.0<1% of people
  2. A;GBad1.26x risk for hypertensionTypical · 0.012% of people
  3. G;GGoodaverageTypical · 0.087% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageA;A <1% A;G 12% G;G 87%
  • European ancestry (Utah)A;A 0% A;G 2% G;G 98%
  • Han Chinese (Beijing)A;A 2% A;G 26% G;G 72%
  • Japanese (Tokyo)A;A 4% A;G 27% G;G 69%
  • Chinese (Denver)A;A 0% A;G 20% G;G 80%
  • Gujarati IndianA;A 1% A;G 17% G;G 82%
  • Luhya (Kenya)A;A 0% A;G 5% G;G 95%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 4% G;G 97%
  • Maasai (Kenya)A;A 0% A;G 4% G;G 96%
  • TuscanA;A 0% A;G 3% G;G 97%

Notes

From SNPedia

Notes

rs3794260, a SNP in the KIAA0789 gene, was associated with risk for hypertension in a study involving 1,500+ Japanese patients. The odds ratio associated with the risk allele, rs3794260(G), which is also the most common allele, is 1.26 (CI: 1.12 - 1.42, p = 0.0001). Note that another SNP in the KIAA0789 gene, rs9739493, was determined to be in a different linkage disequilibrium block, and is thus thought to be an independent risk factor for hypertension.

Source and license

Adapted from rs3794260 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.