rs3798220(C;C)

2-3x higher risk for cardiovascular events, which can be lowered by aspirin

Magnitude
2.6Worth knowing
Repute
Bad
Frequency
<1%Average of 7 populations
On SNPedia
rs3798220(C;C)
Gene
LPA

Frequency

Share of people with C;C in each HapMap population.

  • African ancestry (Southwest US)2%
  • Mexican ancestry (Los Angeles)2%
  • Japanese (Tokyo)<1%
  • Chinese (Denver)<1%
  • Han Chinese (Beijing)<1%
  • European ancestry (Utah)0%
  • Yoruba (Nigeria)0%

Other genotypes of rs3798220

  1. C;TBad2-3x higher risk for cardiovascular events, which can be lowered by aspirinWorth knowing · 2.311% of people
  2. T;TGoodnormalTypical · 0.088% of people

All about rs3798220

Notes

From SNPedia

http://jdmoyer.com/2013/01/28/how-do-you-prevent-heart-disease/ People carrying the C allele produce higher levels of lipoprotein(a), and have more than a twofold increased risk of heart disease. Heart disease risk for rs3798220-C carriers can be somewhat mitigated by low-dose aspirin therapy, at least in women. Estrogen HRT also lowers lipoprotein-a/Lp(a) levels. Among Bantu fishermen, higher fish intake was also associated with lower Lp(a). Why are elevated Lp(a) levels associated with coronary heart disease? Lp(a) is similar to low-density lipoprotein (LDL), which is more likely to stick to arterial walls and clog them up (while the big HDL molecules bounce around harmlessly).

Source and license

Adapted from rs3798220(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.