rs3815148

A SNP in the COG5 gene on chromosome 7. Its most notable genotype is C;C: 1.34x increased risk of Osteoarthritis

Gene
COG5
Location
Chr 7107,297,975 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodnormalTypical · 0.067% of people
  2. A;CBad1.16x increased risk of OsteoarthritisWorth knowing · 2.529% of people
  3. C;CMost notableBad1.34x increased risk of OsteoarthritisImportant · 3.04% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 67% A;C 29% C;C 4%
  • European ancestry (Utah)A;A 61% A;C 35% C;C 4%
  • Han Chinese (Beijing)A;A 58% A;C 38% C;C 4%
  • Japanese (Tokyo)A;A 86% A;C 13% C;C <1%
  • Yoruba (Nigeria)A;A 62% A;C 32% C;C 7%
  • African ancestry (Southwest US)A;A 67% A;C 30% C;C 4%
  • Chinese (Denver)A;A 73% A;C 26% C;C 2%
  • Gujarati IndianA;A 69% A;C 27% C;C 4%
  • Luhya (Kenya)A;A 56% A;C 39% C;C 5%
  • Mexican ancestry (Los Angeles)A;A 72% A;C 26% C;C 2%
  • Maasai (Kenya)A;A 83% A;C 17% C;C 0%
  • TuscanA;A 52% A;C 38% C;C 10%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A;C

Osteoarthritis

C;C

Osteoarthritis

Source and license

Adapted from rs3815148 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.