rs3843763

A SNP in the PLTP gene on chromosome 20. Its most notable genotype is T;T: Slightly lower HDL ("Good") Cholesterol.

Gene
PLTP
Location
Chr 2045,919,554 (GRCh38)
Highest magnitude
1.9Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNormal (higher) HDL "Good" Cholesterol.Minor · 1.6
  2. C;TBadSlightly lower HDL ("Good") Cholesterol.Minor · 1.5
  3. T;TMost notableBadSlightly lower HDL ("Good") Cholesterol.Minor · 1.9

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 170 words

The (T) allele of rs3843763 was associated with risk for lower high-density lipoprotein (HDL) cholesterol plasma levels in 3 independent population samples, including both Caucasians and African-Americans.

C;C

HDL ("Good") cholesterol actually cleans your arteries and transports cholesterol out of the body, so it is usually good to have higher HDL cholesterol.

C;T

This slightly reduces levels of good HDL cholesterol in your blood. And that's usually bad, because HDL cholesterol actually cleans your arteries and transports cholesterol out of your body. Things that can help raise HDL cholesterol if it is too low include: quitting smoking, losing weight, exercise, and niacin (vitamin B3).

T;T

This reduces levels of good HDL cholesterol in your blood. And that's usually bad, because HDL cholesterol actually cleans your arteries and transports cholesterol out of your body. Things that can help raise HDL cholesterol if it is too low include: quitting smoking, losing weight, exercise, and niacin (vitamin B3).

Source and license

Adapted from rs3843763 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.