rs3848519
A SNP in the FECH gene on chromosome 18. Its most notable genotype is A;A: likely to be a benign variant
- Gene
- FECH
- Location
- Chr 1857,580,104 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 2%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedlikely to be a benign variant
- A;CNot ratedlikely to be a benign variant
- C;CGoodcommon in complete genomics
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 0% A;C 4% C;C 96%
- European ancestry (Utah)A;A 0% A;C 2% C;C 98%
- Han Chinese (Beijing)A;A 0% A;C 4% C;C 96%
- Japanese (Tokyo)A;A 0% A;C 2% C;C 98%
- Yoruba (Nigeria)A;A 0% A;C 3% C;C 97%
- African ancestry (Southwest US)A;A 0% A;C 2% C;C 98%
- Chinese (Denver)A;A 0% A;C 4% C;C 96%
- Gujarati IndianA;A 0% A;C 10% C;C 90%
- Luhya (Kenya)A;A 0% A;C 5% C;C 95%
- Mexican ancestry (Los Angeles)A;A 0% A;C 7% C;C 93%
- Maasai (Kenya)A;A 0% A;C 1% C;C 99%
- TuscanA;A 0% A;C 3% C;C 97%
Related
Notes
From SNPedia
Show notes, about 120 words
aka c.163G>T (p.Gly55Cys) Originally reported in OMIM and therefore ClinVar as a recessive variant for erythropoietic protoporphyria, but now considered to be benign or likely benign (in large part because it's seen more frequently than would be expected for a mutation of this type and because the change at the protein level is not considered that impactful).
A;C
aka c.163G>T (p.Gly55Cys) Originally reported in OMIM and therefore ClinVar as a recessive variant for erythropoietic protoporphyria, but now considered to be benign or likely benign (in large part because it's seen more frequently than would be expected for a mutation of this type and because the change at the protein level is not considered that impactful).
Source and license
Adapted from rs3848519 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.