rs3923890

A SNP in the ROBO3 gene on chromosome 11. Its most notable genotype is A;A: lower social interaction

Gene
ROBO3
Location
Chr 11124,870,514 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe
Minor allele frequency
37%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadlower social interactionMinor · 1.016% of people
  2. A;TNot ratedNo summary available.Typical · 0.038% of people
  3. T;TGoodnormal social interactionMinor · 1.045% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 16% A;T 38% T;T 45%
  • European ancestry (Utah)A;A 11% A;T 44% T;T 45%
  • Han Chinese (Beijing)A;A 35% A;T 48% T;T 18%
  • Japanese (Tokyo)A;A 27% A;T 48% T;T 25%
  • Yoruba (Nigeria)A;A <1% A;T 19% T;T 80%
  • African ancestry (Southwest US)A;A 9% A;T 25% T;T 66%
  • Chinese (Denver)A;A 35% A;T 46% T;T 19%
  • Gujarati IndianA;A 17% A;T 47% T;T 37%
  • Luhya (Kenya)A;A <1% A;T 29% T;T 70%
  • Mexican ancestry (Los Angeles)A;A 28% A;T 48% T;T 24%
  • Maasai (Kenya)A;A 3% A;T 28% T;T 69%
  • TuscanA;A 13% A;T 40% T;T 47%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3923890 has been reported to be a SNP potentially associated with increased risk for autism

A;A

Increased risk of autism. Lower social interaction on ADI-R_A test.ncbi.nlm.nih.gov

T;T

Normal autism risk.ncbi.nlm.nih.gov

Source and license

Adapted from rs3923890 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.