rs393152

A SNP in the CRHR1-IT1-CRHR1 gene on chromosome 17. Its most notable genotype is A;A: Increased risk of both PD and AD

Gene
CRHR1-IT1-CRHR1
Location
Chr 1745,641,777 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadIncreased risk of both PD and ADMinor · 1.556% of people
  2. A;GBadSlight increased risk of both PD and ADMinor · 1.231% of people
  3. G;GGoodNormal risk of both PD and ADMinor · 1.313% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 56% A;G 31% G;G 13%
  • European ancestry (Utah)A;A 59% A;G 40% G;G <1%
  • Han Chinese (Beijing)A;A 100% A;G 0% G;G 0%
  • Japanese (Tokyo)A;A 99% A;G <1% G;G 0%
  • Yoruba (Nigeria)A;A 16% A;G 40% G;G 44%
  • African ancestry (Southwest US)A;A 26% A;G 42% G;G 32%
  • Gujarati IndianA;A 82% A;G 17% G;G 1%
  • Luhya (Kenya)A;A 34% A;G 49% G;G 17%
  • Mexican ancestry (Los Angeles)A;A 64% A;G 28% G;G 9%
  • Maasai (Kenya)A;A 41% A;G 45% G;G 14%
  • TuscanA;A 41% A;G 45% G;G 14%

Other CRHR1-IT1-CRHR1 SNPs

All CRHR1-IT1-CRHR1 SNPs

Source and license

Adapted from rs393152 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.