rs3948464

A SNP in the SP110 gene on chromosome 2. Its most notable genotype is G;G.

Gene
SP110
Location
Chr 2230,185,999 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
10%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedNo summary available.Typical · 0.080% of people
  2. A;AGoodcommon in clinvarTypical · 0.02% of people

SNPedia records rs3948464 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 80% A;A 2%
  • European ancestry (Utah)G;G 71% A;A 0%
  • Han Chinese (Beijing)G;G 99% A;A 0%
  • Japanese (Tokyo)G;G 100% A;A 0%
  • Yoruba (Nigeria)G;G 76% A;A 3%
  • African ancestry (Southwest US)G;G 79% A;A 2%
  • Gujarati IndianG;G 91% A;A 1%
  • Luhya (Kenya)G;G 57% A;A 2%
  • Mexican ancestry (Los Angeles)G;G 90% A;A 2%
  • Maasai (Kenya)G;G 57% A;A 8%
  • TuscanG;G 81% A;A 0%

Conditions, medicines and genes

Other SP110 SNPs

All SP110 SNPs

Notes

From SNPedia

Notes

associated with genetic susceptibility to tuberculosis in West Africa Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. SP110 gene polymorphisms and tuberculosis susceptibility: A systematic review and meta-analysis based on 10 624 subjects.

Source and license

Adapted from rs3948464 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.