rs4027132

A SNP on chromosome 2. Its most notable genotype is A;A: 1.51x increased risk of developing bipolar disorder

Gene
None listed
Location
Chr 211,897,366 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.51x increased risk of developing bipolar disorderWorth knowing · 2.028% of people
  2. A;GBad1.39x increased risk of developing bipolar disorderMinor · 1.550% of people
  3. G;GGoodNormal risk of developing bipolar disorderMinor · 1.022% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 28% A;G 50% G;G 22%
  • European ancestry (Utah)A;A 31% A;G 53% G;G 16%
  • Han Chinese (Beijing)A;A 26% A;G 50% G;G 25%
  • Japanese (Tokyo)A;A 24% A;G 48% G;G 28%
  • Yoruba (Nigeria)A;A 31% A;G 46% G;G 23%
  • African ancestry (Southwest US)A;A 23% A;G 56% G;G 21%
  • Chinese (Denver)A;A 16% A;G 51% G;G 34%
  • Gujarati IndianA;A 32% A;G 47% G;G 22%
  • Luhya (Kenya)A;A 28% A;G 55% G;G 17%
  • Mexican ancestry (Los Angeles)A;A 33% A;G 40% G;G 28%
  • Maasai (Kenya)A;A 34% A;G 50% G;G 16%
  • TuscanA;A 30% A;G 53% G;G 17%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs4027132 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (A), and the odds ratio associated with heterozygotes is 1.39 (CI 1.19-1.64), and for homozygotes, 1.51 (CI 1.27-1.79).

Source and license

Adapted from rs4027132 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.