rs403016

A SNP in the FCGR3A gene on chromosome 1. Its most notable genotype is C;C: normal

Gene
FCGR3A
Location
Chr 1161,548,632 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormalWorth knowing · 2.0100% of people
  2. C;GBad2x risk for lupusWorth knowing · 2.00% of people
  3. G;GBad2x risk for lupusWorth knowing · 2.00% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 100% C;G 0% G;G 0%
  • European ancestry (Utah)C;C 100% C;G 0% G;G 0%
  • Han Chinese (Beijing)C;C 100% C;G 0% G;G 0%
  • Japanese (Tokyo)C;C 100% C;G 0% G;G 0%
  • Yoruba (Nigeria)C;C 100% C;G 0% G;G 0%

Conditions, medicines and genes

Other FCGR3A SNPs

All FCGR3A SNPs

Notes

From SNPedia

Notes

SNP rs403016 has been reported from a study of 119 Chinese lupus patients to be associated with an increased risk for developing the disease. The odds ratio is 2.2 (p = 0.028). The risk allele is rs403016(G), which encodes the "72R" (R for arginine) allele.

Source and license

Adapted from rs403016 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.