rs4054823

A SNP on chromosome 17. Its most notable genotype is T;T: 1.26x higher risk of aggressive form of prostate cancer

Gene
None listed
Location
Chr 1713,721,707 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormal risk of aggressive form of prostate cancerTypical · 0.020% of people
  2. C;TNot ratednormal risk of aggressive form of prostate cancerTypical · 0.049% of people
  3. T;TMost notableBad1.26x higher risk of aggressive form of prostate cancerWorth knowing · 2.030% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 20% C;T 49% T;T 30%
  • European ancestry (Utah)C;C 21% C;T 47% T;T 32%
  • Han Chinese (Beijing)C;C 31% C;T 53% T;T 16%
  • Japanese (Tokyo)C;C 22% C;T 50% T;T 28%
  • Yoruba (Nigeria)C;C 4% C;T 40% T;T 56%
  • African ancestry (Southwest US)C;C 18% C;T 42% T;T 40%
  • Chinese (Denver)C;C 25% C;T 51% T;T 24%
  • Gujarati IndianC;C 21% C;T 54% T;T 26%
  • Luhya (Kenya)C;C 23% C;T 45% T;T 32%
  • Mexican ancestry (Los Angeles)C;C 18% C;T 60% T;T 23%
  • Maasai (Kenya)C;C 25% C;T 42% T;T 33%
  • TuscanC;C 18% C;T 60% T;T 23%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 250 words

rs4054823 is a SNP in chromosomal region 17p12. This SNP is associated with risk of aggressive prostate cancer. Most prostate cancers proceed slowly and can be successfully treated even if not detected early. A subset of prostate cancers are an aggressive form which is harder to treat, especially if not detected early. The aggressive form of prostate cancer accounts for an estimated 27,000 deaths annually in the US. A study of 4,829 and 12,205 patients with more and less aggressive disease, respectively, found that the frequency of rs4054823(T;T) was consistently higher among patients with more aggressive compared with less aggressive disease in each of the seven populations studied (overall p = 2.1 x 10e-8). This is not a predictor of increased risk of prostate cancer. Instead, those who do get prostate cancer have a higher risk of it being the aggressive type if they have the risk factor. Those with the risk factor can benefit from more frequent prostate cancer exams, and more aggressive treatment if prostate cancer is found. In the news: Gene may pinpoint most aggressive prostate cancer. Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality. Prostate cancer risk variants are not associated with disease progression.

T;T

The (T;T) genotype does not indicate a higher risk of prostate cancer. It indicates that those with prostate cancer have a 26% higher chance of having the aggressive form which requires more aggressive treatment.

Source and license

Adapted from rs4054823 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.